Lester was the lead singer of the 1960s soul rock group The Chambers Brothers, who had the hit single, “Time Has Come Today.” The song spent five weeks at No. 11 on the Billboard Hot 100 in the fall of 1968, it is considered one of the landmark rock songs of the psychedelic era.
In March 2012 Lester started an Internet campaign to publicize what he claims to be a lack of equitable royalty payments.
On December 10, 2012, Lester Chambers and Alexis Ohanian (Reddit co-founder) teamed up to launch a Kickstarter project together with the intent to make a new album titled Lester’s Time Has Come.Lester also spoke with Reddit users on December 13, 2012, at an AMA (Ask Me Anything) event and to mention the Kickstarter project to those interested.
On July 13, 2013 Lester Chambers was reportedly assaulted onstage during a performance at the Russell City Hayward Blues Festival after dedicating a performance of “People Get Ready” to Trayvon Martin, the day the jury found his killer not guilty of a criminal offense.